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Once-weekly subcutaneous tirzepatide may not raise risk for depression compared with placebo, according to a post hoc analysis of the SURMOUNT trials

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What could that be? In a way, your study found GLP-1s are, at times, working too well

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Several observational studies have reported greater 12-month weight loss with tirzepatide than semaglutide approved for the treatment of type 2 diabetes, but differences in follow-up duration, dosing, and adherence limit comparability with shorter-term outcomes [12, 13]