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Patients experiencing persistent skin dryness, unusual texture changes, or delayed wound healing should discuss nutritional assessment with their healthcare provider, though a direct causal relationship between GLP-1 therapy and specific nutritional deficiencies has not been firmly established
Results in people without diabetes remain mixed
Once-Weekly Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine 384(11) 2021PMID: 33567185 NEJM 4 Jastreboff AM, Aronne LJ, Ahmad NN, et al
Individuals with a BMI of 30 kg/m or higher may qualify directly, while those with a BMI of 27 kg/m or higher may be eligible if they have weight-related health conditions like hypertension, type 2 diabetes , elevated cholesterol, or obstructive sleep apnea
Obesity and aging are associated with altered NAD/Sirtuin 1 (SIRT1)/PARP dynamics [85]
Changes in mitochondrial bioenergetics also affect myocardial ion handling resulting in cytosolic sodium and calcium overload (Trost et al., 2002
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