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The human GS enzyme is a homodimer of subunits containing 474 amino acid residues, encoded by a single-copy gene (Gali and Board, 1997)

Glutathione is a powerful antioxidant naturally produced by the liver and also found in certain foods like fruits, vegetables, and meats

Cell 156(12):317331 Yuan H, Li X, Zhang X, Kang R, Tang D (2016a) CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

TRNA (Ser) SECIS is aminoacylated with serine which is then converted to intracellular Sec [44] from cytoplasm to nucleus in case of exposure to ROS or depending on Se status that modulates Sec-tRNA [Ser] Sec with methylation of Sec in position [45], which modifies the secondary and tertiary structure of Sec-tRNA [Ser] Sec

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