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10.1038/s41467-019-13896-7 Nat
Presented for research literature review only Faxn UL et al
Lyophilized peptides remain stable at room temperature for short periods but should be refrigerated for long-term storage
60 HP 95 DSIP Delta Sleep-Inducing Peptide ALIASES DSIP, delta sleep-inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu CLASS Endogenous nonapeptide sleep / stress-pathway modulator FORMULA C35H48N10O15 SEQUENCE Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu HALF-LIFE Very short (minutes) plasma longer CNS retention reported ROUTES Subcutaneous (research) Intranasal (research) MECHANISM OF ACTION Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit cerebral venous blood during electrically induced sleep states
9ad), but none of these isoforms displayed a dependency in cancer cell line genetic screens (Extended Data Fig
10.1016/j.cell.2013.06.016 140
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