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DiMarchi transformed thinking about the hormones this class oftherapies should mimic, a critical part of their efficacy. Despite critics who doubted obesity was a disease at all, they relentlessly pursued this use case, well beyond being the first 2 to patent it

Think of it as the difference between using a sledgehammer and a precision instrumentboth can achieve the goal, but one does so with far greater finesse

It is a monitoring framework, not a results promise

Indeed, GAPDH mutants that cannot be oxidized impair the cells ability to generate NADPH following oxidative insult [39]