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higher in reference allele carriers
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This shift results in a lighter overall skin tone because pheomelanin yields a pinkish-yellow hue (as seen in people with fair skin or red hair), whereas eumelanin is responsible for brown or black pigmentation
Mostly older animal work, one small human pharmacokinetic study, and one human trial that did not beat placebo
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Others prefer oral products because they do not involve needles
It also leads to inconsistent drug absorption, which can undermine weight loss results and increase side effect unpredictability
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