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It is not appropriate during pregnancy or breastfeeding, in active cancer, or in patients with severely uncontrolled metabolic disease without specialist coordination

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Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research

Lean mass includes muscle

There are also concerns over the implications of the committees decision

References: Chang CH, Tsai WC, Hsu YH, Pang JH