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Primary composite endpoint: Time from randomization to first occurrence of an adjudicated major cardiovascular event (MACE): cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke

Healthcare providers should be aware of this risk and may need to adjust preoperative care plans for patients taking these medications

doi:10.1177/153537020122600402

Combining these therapies that target mesolimbic hedonic hunger and hypothalamic appetite regulation may synergistically affect weight loss

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Long-term timing considerations As you settle into a GLP-1 protocol over months, your side effect profile typically improves significantly