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It is caused by a cluster of pigment-producing cells in the skin and sometimes in deeper tissues
Institute of Physics Publishing Sun X, Berger RS, Heinrich P, Marchiq I, Pouyssegur J, Renner K, Oefner PJ, Dettmer K (2020) Optimized protocol for the in situ derivatization of glutathione with n-ethylmaleimide in cultured cells and the simultaneous determination of glutathione/glutathione disulfide ratio by HPLC-UV-QTOF-MS
