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Among the 25 studies included in the qualitative synthesis (16 in the meta-analysis), 15 focused specifically on serum cobalamin changes (reported by baseline and post-treatment means and standard deviations in pg/mL) and 10 reported homocysteine outcomes (means and standard deviations in mmol/L)

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GHRPs bind to the ghrelin receptor and also inhibit the release of somatostatin, which normally limits GH release

Lack of response may indicate incorrect diagnosis, concurrent deficiencies, or inadequate treatment frequency