The non-accidental ingestion of a very high dose of lipoic acid led to multi-organ failure and subsequent death of an adolescent girl (117)
This work was supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases Grants [R01 DK 070195], [R01 DK102142], and [R01 DK125465], the National Institute of General Medicine Grants [P20 GM103549] and [P30 GM118247]
Consuming a nutritious diet containing foods like whole grains, nuts, eggs, and vegetables can help increase GLP-1 levels, which may aid in managing diabetes and promoting satiety.
For women, pregnancy status may also impact which treatments are safest and most effective
Beyond glycaemic control, they slash cardiovascular risk by up to 26%, reduce the progression of kidney disease, and treat fatty liver and sleep apnoea, among others
Moreover, they also have a positive effect on cardiometabolic risk factors most probably translating to a moderate reduction in the risk of major adverse cardiovascular events that still remain undetermined