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The limited human evidence includes: A randomised double-blind placebo-controlled Phase 2 enema trial in ulcerative colitis with 53 participants, published only as a meeting abstract
Taking the medication earlier in the day might mitigate this
Barbiturates (phenobarbitol), primidone, pyrimethamine, valproic acid, hydantoins should not be taken along with methylcobalamin because their effectiveness is inhibited
This symptom occurs because the vitamin plays a In the nervous system, vitamin B12 helps produce a substance called myelin that shields the nerves and helps them transmit sensations
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