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Cytoskeletal and Extracellular Matrix Coupling : Research indicates that TB-500 might regulate actin polymerization, while BPC-157 could influence extracellular matrix signaling through integrins and adhesion molecules

So far, animal studies report no toxicity or major side effects , even at higher doses

Inhibition of Leukotriene B4-Induced CD11B/CD18 (Mac-1) Expression by BIIL 284, a New Long Acting LTB4 Receptor Antagonist, in Patients With Rheumatoid Arthritis

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Some anecdotal reports suggest it could increase brain excitability

Earlier work also demonstrated the lack of effect of POL on coagulation parameters in rabbits