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Common signs are: Fatigue and weakness Neurological changes, such as numbness or tingling in extremities Megaloblastic anemia, characterized by large, abnormal red blood cells We urge quick medical help if these signs dont go away

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*The schedule may vary depending on the season and weather conditions, so it is very important to reconfirm the day before the tour

Pernicious anaemia usually develops over the age of 50

Normal B12 ranges are typically 160-600 pmol/L, but due to the fact that only 6%-20% of the bodys cobalamin is active, a serum value of 400 pmol/L must be met to ensure adequacy ( Clin Chem 2009;55:2198-2206)