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This added glucagon component is believed to enhance energy expenditure and fat metabolism, underpinning the drugs more aggressive weight-loss profile

This is below the threshold used in clinical studies

The findings indicated that subcutaneous administration of CJC-1295 led to a significant increase in growth hormone levels (2-3-fold for 6 days) and IGF-1 levels (1.5-3-fold for 9-11 days)

Allodynia: a review article

PubMed PMID 9849822 foundational pharmacology report describing Ipamorelin in the experimental systems studied

But they're not a replacement for healthy habits and in some cases not a replacement for surgery either. Gallup found that around three-quarters of people who use GLP-1 drugs found them to be either effective or extremely effective in helping them lose weight.