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8.3 Females and Males of Reproductive Potential Discontinue RYBELSUS in women at least 2 months before a planned pregnancy due to the long washout period for semaglutide [see Use in Specific Populations (8.1)]
Additional observations potentiate that the peptide might promote fibroblast migration, a process relevant to cytoskeletal dynamics and tissue remodeling
Based on class data from the tirzepatide SmPC, GLP-1 and GIP-based therapies may reduce oral contraceptive exposure during initiation and dose escalation
Tirzepatide, the active ingredient in Mounjaro, also suppresses appetite and slows digestion but it mimics two hormones instead of one: GLP1 and GIP
In trials where semaglutide was added on to basal insulin with or without metformin, severe hypoglycemia (requiring the assistance of another person) was reported in 1.5% of semaglutide-treated patients
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