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It is a huge hurdle we and others in the B12 community are working on to overcome
Superoxide dismutase (Cu/Zn-SOD): Copper is a component of the Cu/Zn-SOD antioxidant enzyme that protects cells from superoxide radical damage
Current practice converges around three tiers: The split-dose protocol (250 mcg morning, 250 mcg 3+ hours post-meal in the evening) creates two daily windows of lipolytic stimulation
The RDA is 2.4 mcg per day for adults 19-50 and 3.0 mcg for adults 51+
& Meier-Ewert, K
If you experience persistent fatigue , it usually resolves as your body adapts
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