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You do not want only synthesis without clearing damaged tissue, and you do not want only breakdown without rebuilding
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Additionally, individuals taking medications that may interact with B12, including metformin or proton pump inhibitors, should consult a healthcare provider before starting supplementation
There is every reason to expect new treatment possibilities to continue emerging
It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients
