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[6] Because NAD + -dependent enzymes are involved in DNA repair, protein deacetylation, stress responses, mitochondrial function, and cellular signaling, NNMT-related changes in NAD + availability should be interpreted in a pathway-specific manner rather than as a simple beneficial-or-harmful binary
Individuals with methylation issues, such as those with MTHFR variants, might respond differently to NNMT inhibition
The Dutch National Health Counsel and the Regional Disciplinary Medical Board of Eindhoven have stated clearly that vitamin B12 is non-toxic
A clinical review can determine whether B12 testing, another laboratory evaluation, dietary changes, oral treatment, or prescription replacement is appropriate
In some cases, symptoms that appear to be a simple injury may require medical evaluation
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