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Studies finding protective effects against cancer: A meta-analysis found that two copies of the C677T variant (AA genotype) decrease the risk of colon cancer by about 20%![ref] Another meta-analysis found that two copies of the C677T variant (AA genotype) were protective against prostate cancer .[ref] The MTHFR C677T variant decreases the relative risk of retinoblastoma and oral squamous cell cancer.[ref][ref] Two copies of the C677T variant (AA genotype) are protective against gastric cancer.[ref] However, for someone who has cancer, the MTHFR C677T variant is associated with poorer outcomes.[ref] The MTHFR A1298C variant (GG or GT) is associated with a decreased risk of hypothyroidism .[ref] The flip side: Folate can also help protect against cancerous mutations in the first place
The most prevalent and clinically validated strategy utilizes enzymatically cleavable linkers, which leverage the high activity of specific lysosomal proteases (e.g., cathepsin B)
The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE(-/-) mice by blocking monocyte/macrophage activation
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