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found that DHA triggered ferroptosis to eliminate the activation of HSC, which characterized by iron overload, GSH depletion, lipid ROS accumulation, and peroxidation, whereas Fer-1 and Lip-1 inhibited the DHA effect (93)
Studies show decreased levels of malondialdehyde (MDA) and lipid peroxidation products in treated animals, indicating reduced oxidative injury to cellular membranes
Glutathione may interact with certain medications
These radical species may further damage macromolecules, increasing levels of redox-derived DAMPs which further engage TLRs in a self-sustaining cycle
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