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Potential causes include medication interactions (particularly with diabetes medications), thyroid dysfunction, severe insulin resistance, genetic factors affecting GLP-1 receptor function, or gastrointestinal issues preventing medication absorption
Outcomes The primary outcome was the measurement of total testosterone levels before and after GLP-1 RAs administration, chosen for its strong association with the clinical manifestations of hypogonadism in men
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The metabolic sensors in these cells respond to glucose as described above, and GLP-1 treatment reversed the glucose effects [83]
Set against that, the real-world data shows the majority of patients discontinue within a year anyway, with side effects and cost as the two leading documented reasons
