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Sep 2016;67(6):606-13
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Deletion of PLC-3 or PLC-4 genes showed no phenotypic effects in mice, but sperms from PLC-4-deficient mice showed a defective acrosomal reaction, a process required for fertilization ( PLC- PLC-, first identified in Caenorhabditis elegans , is the largest PLC isoform cloned to date, with a molecular weight of 250 kDa
Nature Structural Biology 10, 19-25
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