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Consequently, riboflavin is also included as additional prophylactic therapy in the treatment guidelines of conditions and disorders with co-morbid migraine headaches 70

Zeng J, Yang W, Shi D, Li X, Zhang H, Chen M

5 BatlaA.SimeoniS.UchiyamaT.deMinL.BaldwinJ.MelbourneC.et al (2021)

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Diagnosis typically involves a combination of lab testing (e.g., tryptase, histamine, prostaglandins, chromogranin A), symptom correlation, and clinical evaluation

Another RCT in Indonesia (Evaluating Oral Glutathione Plus Ascorbic Acid, Alpha-lipoic Acid ) found modest improvements in skin tone but they were not statistically significant overall