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37 Most reports estimate the prevalence of painful DPN (PDPN) among diabetes patients to be between 13 and 35%

ACS Synth Biol 7(1):121131 Zanichelli F, Capasso S, Cipollaro M, Pagnotta E, Carten M, Casale F, Iori R, Galderisi U (2012) Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect

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One of the most exciting approaches is the use of novel delivery systems

This review analyzes the advances in nano-phytomedicine for brain disorders, focusing on how nanocarriers and bloodbrain barrier-crossing strategies enhance the efficacy of neuroprotective phytochemicals