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Licensing (Marketing Authorisation): The MHRA has approved: Semaglutide (Wegovy) for adults with BMI 30 kg/m or BMI 27 kg/m with at least one weight-related comorbidity Liraglutide (Saxenda) with similar BMI criteria NHS Access (NICE Guidance): According to NICE guidance (TA664 for semaglutide), NHS-funded treatment is more restricted and typically available for adults with: BMI 35 kg/m with at least one weight-related comorbidity (such as hypertension, type 2 diabetes, dyslipidaemia, obstructive sleep apnoea, or cardiovascular disease) For individuals from Black, Asian, and minority ethnic backgrounds, lower BMI thresholds may apply, recognising that these populations face increased metabolic risk at lower BMI levels

Researchers can use this data to optimize COA design or selection regardless of modality, target demographic, or indication, with potential positive effects on comparability, translatability, data quality, and the patient experience, as COAs and expectations about them converge on more straightforward and familiar structures and language

If food strategies are not enough, a conversation with your clinician usually is

To test the anticancer effect of intermittent fasting from dawn to sunset in metabolic syndrome, we conducted a pilot study in 14 subjects with metabolic syndrome who fasted (no eating or drinking) from dawn to sunset for more than 14 h daily for four consecutive weeks

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Gregory Sheehy, M.D., Clinical Professor of Medicine Department of Medicine, Section of General Internal Medicine University of Wisconsin Medical School Madison, WI January 26, 2005