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Randomized Controlled Trial of Semaglutide for Alcohol Use Disorder In a randomized controlled Phase 2 trial of semaglutide for alcohol use disorder (AUD), Christian Hendershot at UNC / USC found significant reductions in drinking among people taking semaglutide, particularly in reducing heavy drinking days

Neurology 93 , e2294e2305 (2019)

286 Kholodenkos Modular Response Analysis (MRA) and Boolean network simulations can identify minimal intervention setscombinatorial targets whose simultaneous inhibition destabilizes the adaptive network, precluding escape and restoring vulnerability

Intestinal Barrier Dysfunction: Preclinical evidence suggests that by lowering systemic oxidative stress, NAC may promote intestinal barrier integrity and support a healthy balance of intestinal microbiota, addressing the gut dysbiosis often seen in chronic illness

Lost more weight at each check-in point during the study (3 months, 6 months, and 1 year) A separate study of adults with type 2 diabetes had similar findings