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In REDEFINE 1, Novo randomized more than 3,400 participants, all of whom had at least one weight-related comorbidity, to receive cagrilintide, semaglutide, CagriSemaa fixed-dose combination of the other two drugsor placebo

Avoid Sugary Snacks : Minimize processed sugars and high-calorie snacks like candies, sodas, or fast food

For most people, the worst of the GI effects resolve within 4 to 6 weeks of reaching a new dose level

Treatment was discontinued more often in the semaglutide group, primarily driven by gastrointestinal disorders (14.7% vs 9.0% in the heart failure groups

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Reconstituted retatrutide is typically stable for 28 to 60 days when refrigerated at 36-46F (2-8C), based on general bacteriostatic water peptide compounding principles