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The 6-SNP threshold was chosen based on the range of SNP distances between paired isolates of the same strain obtained at different times from relapsed TB patients 63

However, neither BAL fluid nor intracellular GSH, GSSG, and GSH:GSSG correlated with BAL eosinophils or any other inflammatory cell, suggesting eosinophilia plays a lesser role in contributing to higher extracellular/BAL fluid GSSG than epithelial cells do (Supplemental Tables 3 and 4)

The way to alleviate these symptoms is to slow down the rate of infusion, or to receive NAD via another route, such as injections

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El Hadri K, Smith R, Duplus E, El Amri C