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RAAS blockade and SGLT2 inhibitors are both associated with significant renal hemodynamic mediated dips in GFR, which may limit their use in patients with renal function at lower limits of clinical trial inclusion criteria (30 mL/min in the CREDENCE trial or 25 mL/min in the DAPA-CKD trial)

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Company reports lower GI side effects than existing GLP-1 therapies

Over time, this reduced nutrient intake could lead to or worsen anemia

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