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McKenzie AL et al

Moreover, the structure of EcGGT in complex with glutathione clearly illustrates the formation of a covalent bond between the OG atom of Thr391 and carbonyl carbon of -glutamyl moiety of glutathione (Okada et al., 2006)

Research using MT-1 in cell systems expressing MC1R variants associated with red hair and fair skin has characterised reduced cAMP signalling responses, impaired MITF activation, and decreased melanogenesis , documenting the functional consequences of loss-of-function MC1R polymorphisms at the receptor signalling level and establishing the molecular basis for the reduced photoprotective melanogenesis capacity associated with these variants

Schauer PR, Bhatt DL, Kirwan JP, et al

1c and d)

GCL is a heterodimer comprising a catalytic subunit (GCLC) and a regulatory subunit (GCLM) 47