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Available from: Okawa M, Mishima K, Nanami T, et al

chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease

Martensson et al, 1990

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These documents typically summarize analytical methods used during quality control processes, such as chromatographic purity analysis or molecular mass confirmation