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The design work is described by Lau and colleagues (Journal of Medicinal Chemistry, 2015)
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The response to treatment appeared to be stronger in women who received MSCs loaded on a collagen scaffold, a fibrillary network that helps retain the stem cells in the ovary
This anion then quickly breaks a disulfide bond (Cys58 - Cys63) and leads to Cys63's nucleophilically attacking the nearest sulfide unit in the GSSG molecule (promoted by His467), which creates a mixed disulfide bond (GS-Cys58) and a GS-anion
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