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It should be avoided or used only under clinician supervision in patients with kidney disease, older adults, or those at risk for electrolyte abnormalities , due to the risk of hypermagnesemia., Use sparingly: Stimulant laxatives (such as bisacodyl or senna) may be effective for intermittent rescue use , but they can cause cramping and are generally not needed for routine long-term management when osmotic agents are effective., Safety note: Regular stimulant laxative use that causes frequent loose stools may contribute to dehydration and electrolyte imbalance (including hypokalemia) and should therefore be intermittent unless clinician-directed . What about docusate (Colace)

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Lofton says

Furthermore, to evaluate the blockade of autophagic flux by PFOS, lysosomal inhibitor chloroquine (CQ) was added to PFOS-treated RTCs during the final hour of the 4-h PFOS treatment

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