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Hercynylcysteine sulfide can also be synthesized from an L-histidine derivative with an N -benzyl-protected imidazole in good yield, followed by a non-enzymatic reaction with pyridoxal phosphate to yield EGT (Khonde and Jardine 2015

These outcomes highlight the intrinsic limitations of extrapolating from animal models, where dopamine circuitry and PDE10A distribution differ substantially from the chronically medicated, pathophysiologically altered human brain (Umbricht et al., 2021)

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