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Although large studies show that for most GLP-1 patients, at least half the lost weight simply piles right back on 2 when they cease treatment, other studies show slow tapering of 2.5mg of semaglutide 3 can be successful. GLP-1 weight-loss medications: pros and cons Weight loss is not the only upside of GLP-1s, according to a landmark 2024 New England Journal of Medicine study4

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