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Given the minimum TTO taken as 1, improper handling of TTO=0 cases in calculations may explain this deviation, and the same issue can also be noted in other tirzepatide studies

While drowsiness is not a recognized side effect of semaglutide (Ozempic, Wegovy, Rybelsus), fatigue is listed as a common adverse reaction in FDA labeling, particularly for Wegovy

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These combinations should always be discussed with a healthcare professional rather than self-directed