To make a correlation that GLP-1s cause NAION would be a big leap, she said
These benefits disappear when you stop, removing multiple mechanisms that were supporting weight maintenance
Oral semaglutide in type 2 diabetes
Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Mishra L
To determine the direct effect of exendin 939 on the time that mice spent licking their hind paws in the CAP-induced spontaneous pain model, intraplantar administration of exendin 939 (doses of 5 and 10 g) was followed by intraplantar administration of CAP (1.6 g)
Experiments were conducted using DIO male C57BL/6J mice (Janvier Labs) kept on a HFHS diet (58 kcal% fat, D12331i, Research Diets) from 8 weeks of age