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Boston, MA: American Botanical Council, 1998

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The manufacturer's guidance distinguishes between unopened pens, which should remain refrigerated between 2C and 8C, and in-use pens, which may be kept at room temperature (not exceeding 30C) for up to 6 weeks

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Higher doses tend to cause constipation more often than lower doses

Discussion The original method faced several challenges, including the need for strong acids to terminate the enzymatic reaction, which could be hazardous and affect the accuracy of the measurement