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The abundance of several proteins including two GSTs (AtGSTF7 and AtGSTU7) markedly increased (Mukherjee et al., 2010)
Stanley et al
Other telomerase inhibitors like tetra-(N-methyl-4-pyridyl) porphine (TMPyP4), berberine, and telomestatin inhibit telomere elongation via interacting with quadruplex DNA [55,56,57]
Further, the NADH from increased glycolysis in the cytosol can be transferred to mitochondria to drive NADH-dependent NNT
But that entire safety dataset is three small animal studies with no formal toxicology arm, no dose escalation, no repeat dosing, no long-term follow-up, and nothing in humans
The dosing variance from rounding is clinically insignificant
