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While even extremely high doses of GHK-Cu are unlikely to cause any adverse reactions, Pickart has estimated that the peptide can produce toxic action and start lowering a subjects blood pressure starting from an astronomical dose of about 22,500mg [13]
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Interestingly, GIPR agonism blocks PYY (155) and GLP-1 receptor mediated emesis and illness behaviors in preclinical species (156)
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