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Semaglutide is also considered a long-acting GLP-1 receptor agonist, alongside other GLP-1 agonist drugs.2 Adverse & Severe Adverse Effects of GLP-1 Agonist Drugs The use of GLP-1 agonist drugs may result in some adverse effects, severe adverse effects, and other undesirable effects that impact any time of rapid weight loss due to caloric restriction