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APAP-associated hepatotoxicity is ameliorated by promoting the Nrf2 system in mice without PTP1B or M1R, indicating that PTP1B and/or M1R may be promising therapeutic targets in ALI

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Following withdrawal of NFT, Nrf2 levels rapidly declined below the detection limit, whereas GCLC levels remained significantly higher than those observed in the untreated control even after 24 h in the absence of NFT

Thats when I realized this wasnt just a problem for my patients