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In the trial, participants who were 50 years of age or older, had type 2 diabetes with a glycated hemoglobin level of 6.5 to 10.0%, and had known atherosclerotic cardiovascular disease, chronic kidney disease, or both received either once-daily oral semaglutide (maximal dose, 14 mg) or placebo, in addition to standard care

Research suggests that metabolic rate may decrease beyond what would be predicted by tissue loss alone, creating a moving target where the caloric deficit that initially produced weight loss becomes insufficient over time

In some cases, this could result in rebound weight gain, especially if behavioral changes have not occurred alongside medication use

"Prospective Alzheimer's drug builds new brain cell connections, improves cognitive function of rats"

Hypothalamic Interaction: Modulates hypothalamic nuclei involved in sleep and hormone release [Przewlocki 1983]

Jeanne Smith My experience has been wonderful