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Bundle-specific associations between white matter microstructure and A and tau pathology in preclinical Alzheimers disease

Starting Dose: 0.25 mg (250 mcg) once daily Maintenance Dose: 0.25 to 0.5 mg daily, single or split dosing Duration: 4-6 weeks for acute injuries, 6-8 weeks for chronic issues Injection Site: Subcutaneous near injury site or abdominal fat for systemic Frequency: Once daily (some prefer twice daily split doses) Dosing frequency presents some flexibility

Agents that normalize tumor vessels or loosen extracellular matrix may have off-target actions in healthy organs, especially in tissues with active remodeling such as bone marrow, gut or healing wounds

, 68 , 1184-1192, doi: Liu, Y., Liu, T., Lei, T., Zhang, D., Du, S., Girani, L., Qi, D., Lin, C., Tong, R., and Wang Y

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doi:10.1111/j.1464-410x.2007.07205.x