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These drugs, beyond their specific effects, elicit also a cellular stress including an unbalance of redox state that is counteracted not only utilizing antioxidant species but also increasing the outcome export by transporters to detoxify the internal environment
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Consistently, the co-transfection assay of COP1-binding defective DET1 mutants including R488A/H485G, R488A/H485G/R306G/S312G and R488A/H485G/E380A/T382A with COP1 and Ube2e2 demonstrated that the reduction of COP1-DET1 interaction resulted in the decreased amount of Ube2e2 co-purification, suggesting that DET1-mediated proximity is not sufficient for COP1 and Ube2e2 to directly interact (Fig
Plant J 52 (5): 973-86
Glutathione: 250500 mg per day (liposomal or s-acetyl form)
These positive effects observed in histidine and carnosine could be associated with reactive oxygen species (ROS) scavenging
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