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(2004), demonstrating on synaptosomal preparations from mouse cerebral cortex that activation of sst 2 presynaptic receptors may inhibit the cAMP/PKA pathway stimulated by high potassium concentration, leading to a decrease of the evoked glutamate release

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Its shorter half-life necessitates more frequent dosing

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The following regions of the Fab 3F52 heavy chain overlap the entire N-terminal half of the GLP-1 -helix (Thr 13 -Ala 24 ): the tip of CDR2 (Ser 53 -Ser 55 ), part of CDR1 (Ser 31 -Tyr 33 ), Ile 29 -Thr 30 next to CDR1 and a framework 3 (FR3) loop defined by Asp 73 -Lys 76