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doi:10.2337/dc14-1850 46
A dysfunction in System Xc- results in reduced cysteine availability, which limits GSH synthesis, weakens antioxidant defenses, and increases susceptibility to lipid peroxidation, thereby accelerating ferroptosis (67)
Dihexa has not received FDA approval for any medical condition
In summary, we found that the transcription of GPX4 driven by C5aR1 is an epigenetic element of ferroptosis regulation in GBM and has important implications for the progression of GBM
Campbell-Smith E, Holmes NM, Lingwai NW, Panayi MC, Westbrook RF
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