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found that TMAO promoted the release of pro-inflammatory cytokines such as IL-1 and TNF- to stimulate the cardiac autonomic nervous system (CANS) and worsen ischemia-induced VA (127)

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The first peptide described with incretin activity was the gastric inhibitory polypeptide (GIP) that went on to be referred to also as the glucose-dependent insulinotropic polypeptide GIP)

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