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How it works: G-actin sequestration: TB-500 binds G-actin in a 1:1 complex, maintaining a pool of monomeric actin that cells can quickly mobilize for cytoskeletal remodeling and migration toward injury sites (structural basis confirmed in PMC517612)

It aids in tendon, ligament, muscle, and soft tissue recovery while substantially lowering inflammation

Modulate immune responses

The blood-brain barrier (BBB), which normally protects the central nervous system from circulating pathogens and toxins, also blocks most therapeutic molecules from entering the brain

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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation